Planning and Conducting a Pharmacogenetics Association Study

Pharmacogenetics (PGx) association studies are used to discover, replicate, and validate the between an inherited genotype a treatment outcome. The objective of this tutorial is provide trainees novice PGx researchers with overview major decisions that need be made when designing conducting study. first critical decision determine whether study discovery, replication, or validation. Next, researcher must identify patient cohort has all data necessary conduct intended analysis. Then, investigator select define outcome, phenotype, will analyzed. what genotyping approach genetic included in Finally, phenotype tested using some statistical analysis methodology. This divided into five sections; each section describes commonly approaches provides suggestions resources for Successful discover associations variation outcomes, which enable clinical translation improve efficacy reduce toxicity treatment.